LAB EVENT

Lab Photos

Journal Club

2024

June

• Long 30UTRs predispose neurons to inflammation by promoting immunostimulatory double-stranded RNA formation
• Structures of α-synuclein filaments from human brains with Lewy pathology

May

• α-Synuclein–induced Kv4 channelopathy in mouse vagal motoneurons drives nonmotor parkinsonian symptoms
• Aβ oligomers trigger necroptosis‑mediated neurodegeneration via microglia activation in Alzheimer’s disease
• Peripheral neuronal activation shapes the microbiome and alters gut physiology

April

• Transcript errors generate a continuous stream of amyloid and prion-like proteins in human cells
• Fiber deprivation and microbiome-borne curli shift gut bacterial populations and accelerate disease in a mouse model of Parkinson’s disease
• Neuronal lysosome transfer to oligodendrocyte precursor cells a novel mechanism of neuron-glia communication and its role in neurodegenerative diseases
• Brain-to-gut trafficking of alpha-synuclein by CD11c+ cells in a mouse model of Parkinson’s disease

February

• Death Induced by Survival gene Elimination (DISE) correlates with neurotoxicity in Alzheimer’s disease and aging
• Mitochondrial DNA damage triggers the spread of Parkinson’s disease-like pathology
• Gut mucosal cells transfer α-synuclein to the vagus nerve

January

• P.mirabilis-derived pore-forming haemolysin, HpmA drives intestinal alpha-synuclein aggregation
• Mesoscale connections and gene expression empower whole-brain modeling of α-synuclein spread, aggregation, and decay dynamics

2023

December-November

• Co-transplantation of autologous Treg cells in a cell therapy for Parkinson’s disease
• NK cells clear α-synuclein and the depletion of NK cells exacerbates synuclein pathology in a mouse model of α-synucleinopathy
• Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology
• Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy

October

• STING mediates neurodegeneration and neuroinflammation in nigrostriatal α-synucleinopathy
• Quantitative Detection and Real-Time Monitoring of Endogenous mRNA at the Single Live Cell Level Using a Ratiometric Molecular Beacon
• Generation of human striatal-midbrain assembloids from human pluripotent stem cells to model alpha-synuclein propagation

August

• Characterization of altered molecular mechanisms in Parkinson’s disease through cell type–resolved multiomics analyses
• Immune cells aid therapy for Parkinson’s disease
• A Neural Circuit for Gut-Induced Reward

July

• The Rab5 effector FERRY links early endosomes with mRNA localization
• Spread of α-synuclein pathology through the brain connectome is modulated by selective vulnerability and predicted by network analysis
• HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease

June

• Single nucleus multiomics identifies ZEB1 and MAFB as candidate regulators of Alzheimer’s disease-specific cis-regulatory elements
• Multiplexed CRISPR technologies for gene editing and transcriptional regulation

May

• Plaque contact and unimpaired Trem2 is required for the microglial response to amyloid pathology
• Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer’s disease
• Mapping spatial transcriptome with light-activated proximity-dependent RNA labeling

April

• Functional regulatory variants implicate distinct transcriptional networks in dementia
• The Parkinson’s disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability
• Optogenetic polymerization and assembly of electrically functional polymers for modulation of single-neuron excitability

March

• Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
• On-demand cell-autonomous gene therapy for brain circuit disorders
• Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models

January-February

• Basic principles of hydrogel-based tissue transformation technologies and their applications
• Targeting thalamic circuits rescues motor and mood deficits in PD mice
• Solving brain circuit function and dysfunction with computational modeling and optogenetic fMRI

2022

• A single-cell transcriptomic atlas characterizes ageing tissues in the mouse
• Altered human oligodendrocyte heterogeneity in multiple sclerosis
• Reversing a model of Parkinson’s disease with in situ converted nigral neurons
• Powerful Homeostatic Control of Oligodendroglial Lineage by PDGFRa in Adult Brain
• Oligodendrocytes express synaptic proteins that modulate myelin sheath formation
• The Parkinson’s disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability
• A gut-brain neural circuit for nutrient sensory transduction
• Single-cell multiome of the human retina and deep learning nominate causal variants in complex eye diseases
• Disruption of cellular proteostasis by H1N1 influenza A virus causes α-synuclein aggregation
• Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson’s disease
• Dysfunction of striatal MeCP2 is associated with cognitive decline in a mouse model of Alzheimer’s disease
• Oligodendroglia heterogeneity in the human central nervous system
• Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals
• Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state
• Hippocampal astrocytes encode reward location
• Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia
• GPNMB confers risk for Parkinson’s disease through interaction with a-synuclein

2021

• Amyloid-Beta (Ab) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Ab Pathology
• Single-cell transcriptomic profiling of the aging mouse brain
• Generation of homogeneous midbrain organoids with in vivo-like cellular composition facilitates neurotoxin-based Parkinson’s disease modeling
• Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer’s and Parkinson’s diseases
• SCN2A contributes to oligodendroglia excitability and development in the mammalian brain
• Programmable RNA targeting with the single-protein CRISPR effector Cas7-11
• Translation of intrinsically disordered α-synuclein protein is inhibited by a small molecule targeting a structure in its mRNA
• NG2+ CNS Glial Progenitors Remain Committed to the Oligodendrocyte Lineage in Postnatal Life and following Neurodegeneration
• Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis
• Targeted Complement Inhibition at Synapses Prevents Microglial Synaptic Engulfment and Synapse Loss in Demyelinating Disease
• Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system
• Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA
• Higher levels of myelin phospholipids in brains of neuronal α-Synuclein transgenic mice precede myelin loss
• Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies
• Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies
• Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin
• Brain cell type-specific enhancer-promoter interactome maps and disease-risk association
• Oxidative Stress Promotes Uptake, Accumulation, and Oligomerization of Extracellular α-Synuclein in Oligodendrocytes
• Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates
• A systematic benchmark of Nanopore long-read RNA sequencing for transcript level analysis in human cell lines
• Large-scale proteomic analysis of the human brain identifies proteins associated with cognitive trajectory in advanced age
• Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease

2020

• Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease
• Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis
• Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies
• Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease
• Binding of α‑synuclein oligomers to Cx32 facilitates protein uptake and transfer in neurons and oligodendrocytes
• Reversing a model of Parkinson’s disease with in situ converted nigral neurons
• Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson’s disease
• Pum2 Shapes the Transcriptome in Developing Axons through Retention of Target mRNAs in the Cell Body
• Oligodendrocytes as A New Therapeutic Target in Schizophrenia: From Histopathological Findings to Neuron-Oligodendrocyte Interaction
• Probiotic Bacillus subtilis Protects against a-Synuclein Aggregation in C. elegans
• Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration
• Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson’s Disease
• Human autologous iPSC–derived dopaminergic progenitors restore motor function in Parkinson’s disease models
• Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life
• Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice
• Characterizing dysbiosis of gut microbiome in PD: evidence for overabundance of opportunistic pathogens
• Discriminating α-synuclein strains in Parkinson’s disease and multiple system atrophy
• Search-and-replace genome editing without double-strand breaks or donor DNA
• Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2 production
• A systematic benchmark of Nanopore long-read RNA sequencing for transcript level analysis in human cell lines
• α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease
• Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease